Can information captured via high resolution microscope images Particle Vision and Measurement, or PVM significantly improve crystallization? A new METTLER TOLEDO white paper sets out to answer this question using real-world image comparisons that reveal how PVM provides previously unobtainable data that leads to easier, faster product development and scale-up.
METTLER TOLEDO is pleased to present the next installment in its thought-leading white paper series, "How In Situ Vision Simplifies Crystallization and Precipitation." The new white paper, available as a free download, gives critical insight into how Particle Vision and Measurement (PVM) can help improve crystal yield, purity, form, and size/shape distribution for significant productivity gains when developing and scaling potentially error-prone crystallization processes.
The white paper explores various crystallization scenarios that typically present difficulties for engineers and scientists in many industries. Experiments from world wide pharmaceutical manufacturers Merck & Co. and GlaxoSmithKline (GSK) as well as European research giant SINTEF are presented as examples. Still images of dynamic mechanisms such as crystal growth and agglomeration using the probe-based vision technology are compared against images of those same crystallization mechanisms captured with offline sampling.
Captured images explore how PVM visualizes crystallization parameters such as growth, nucleation, agglomeration, breakage and shape change with little ambiguity, allowing for clear quantification. Additionally, data that is simply unobtainable via offline sampling is shown to identify transient or elusive crystallization mechanisms at the root of poor crystallization that impact crystal size and impurity profiles.
Example experiments show how PVM enables the kind of evidence-based process decisions that help scientists and engineers deliver desired crystallization parameters in less time for faster product development. Less waste and more consistent filtration, drying and formulation in scale-up and production typically follow for valuable time and cost-savings.
For more on how inline particle size distribution and shape analysis can help with timely development of optimum crystallization processes, download the white paper free at Crystallization Knowledge, precipitation
About Mettler Toledo:
METTLER TOLEDO specializes in the area of precision instruments for professional use. METTLER TOLEDO laboratory instruments are used in research, scientific, drug discovery, and quality control labs, amongst many others in the pharmaceutical, chemical, food and cosmetics industries. METTLER TOLEDO comprehensive industrial solutions cover the various steps in a host of manufacturing processes at many of the same customers that laboratory serves. Solutions range from receiving raw materials through various manufacturing processes, in-line process control and end-of-line packaging control, to logistics and shipping. Increasingly, these solutions are fully integrated into the customer's IT environment, helping automate their workflows. In food retail, our offering for fresh food management ranges from receiving and pre-packaging, to in-store solutions for self-service departments, deli counters, and checkout terminals.
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